Intron Loss

Introns are part of the dark matter of the genome- DNA sequence with an unknown purpose. Adding to the mystery, introns are sometimes lost or gained from the same gene in different lineages. We discovered that ABCB1 (an agronomically important dwarfing gene in sorghum) showed surprisingly high variation in introns among closely related species in the grass family. We extended our search to more distantly related species to get a better idea of how introns in this gene behaved through time and what features of the gene might contribute to intron instability.

Victoria DeLeo
Postodoctoral Research Associate